/* Custom styles for INSITE using Material Design */
.sidebar {
    position: fixed;
    top: 0;
    bottom: 0;
    left: 0;
    z-index: 100;
    padding: 48px 0 0;
    background-color: var(--md-sys-color-surface-container);
    box-shadow: var(--md-sys-elevation-level2);
    transition: transform 0.3s ease-in-out;
}

.sidebar .nav-link {
    font-weight: 500;
    color: var(--md-sys-color-on-surface);
    padding: 0.75rem 1rem;
    margin: 0.25rem 0;
    border-radius: 12px;
    transition: all 0.2s ease-in-out;
}

.sidebar .nav-link:hover {
    color: var(--md-sys-color-primary);
    background-color: var(--md-sys-color-primary-container);
}

.sidebar .nav-link.active {
    color: var(--md-sys-color-on-primary-container);
    background-color: var(--md-sys-color-primary-container);
}

.sidebar .nav-link i {
    margin-right: 0.5rem;
}

main {
    margin-left: 240px;
}

/* Mobile menu button */
.mobile-menu-btn {
    position: fixed;
    top: 15px;
    left: 15px;
    z-index: 1050;
    background: var(--md-sys-color-primary);
    border: none;
    color: var(--md-sys-color-on-primary);
    padding: 12px;
    border-radius: 12px;
    display: none;
    box-shadow: var(--md-sys-elevation-level2);
    transition: all 0.2s ease-in-out;
}

.mobile-menu-btn:hover {
    background: var(--md-sys-color-primary-container);
    color: var(--md-sys-color-on-primary-container);
    box-shadow: var(--md-sys-elevation-level3);
}

@media (max-width: 767.98px) {
    .mobile-menu-btn {
        display: block;
    }
    
    .sidebar {
        transform: translateX(-100%);
        padding-top: 60px;
    }
    
    .sidebar.show {
        transform: translateX(0);
    }
    
    main {
        margin-left: 0;
        padding-top: 60px;
    }
}

/* Card hover effects */
.card {
    background-color: var(--md-sys-color-surface-container-low);
    border: 1px solid var(--md-sys-color-outline-variant);
    -border-radius: 12px;
    transition: all 0.2s ease-in-out;
    box-shadow: var(--md-sys-elevation-level1);
}

.card:hover {
    box-shadow: var(--md-sys-elevation-level2);
}

.card-header {
    background-color: var(--md-sys-color-surface-container);
    border-bottom: 1px solid var(--md-sys-color-outline-variant);
    color: var(--md-sys-color-on-surface);
}

.card-body {
    color: var(--md-sys-color-on-surface);
}

/* Custom button styles */
.btn-primary {
    background-color: var(--md-sys-color-primary);
    border-color: var(--md-sys-color-primary);
    color: var(--md-sys-color-on-primary);
    border-radius: 20px;
    padding: 8px 24px;
    font-weight: 500;
    transition: all 0.2s ease-in-out;
}

.btn-primary:hover {
    background-color: var(--md-sys-color-primary-container);
    border-color: var(--md-sys-color-primary-container);
    color: var(--md-sys-color-on-primary-container);
    box-shadow: var(--md-sys-elevation-level2);
}

/* Form styling */
.form-select, .form-control {
    border-radius: 12px;
    border: 1px solid var(--md-sys-color-outline);
    background-color: var(--md-sys-color-surface-container-highest);
    color: var(--md-sys-color-on-surface);
    transition: all 0.2s ease-in-out;
}

.form-select:focus, .form-control:focus {
    border-color: var(--md-sys-color-primary);
    box-shadow: 0 0 0 0.2rem var(--md-sys-color-primary-container);
}

.form-label {
    color: var(--md-sys-color-on-surface);
    font-weight: 500;
}

/* Disabled form control styling */
.form-control:disabled, .form-select:disabled, .btn:disabled {
    background-color: var(--md-sys-color-surface-variant) !important;
    border-color: var(--md-sys-color-outline-variant) !important;
    color: var(--md-sys-color-on-surface-variant) !important;
    opacity: 1 !important;
}

/* Alert styling */
.alert-info {
    background-color: var(--md-sys-color-tertiary-container);
    border-color: var(--md-sys-color-tertiary);
    color: var(--md-sys-color-on-tertiary-container);
    border-radius: 12px;
}

/* Compact filter toolbar */
.border {
    border-color: var(--md-sys-color-outline-variant) !important;
}

.rounded-3 {
    background-color: var(--md-sys-color-surface-container-low);
}

.form-select-sm {
    font-size: 0.875rem;
    padding: 0.375rem 0.75rem;
}

.btn-sm {
    font-size: 0.875rem;
    padding: 0.375rem 0.75rem;
}

/* Image styling */
img.img-fluid {
    border-radius: 12px;
    box-shadow: var(--md-sys-elevation-level1);
}

/* Logo styling */
.logo {
    height: 120px;
    width: auto;
}

.umap-plot {
    max-height: 600px;
    border-radius: 12px;
}

/* Additional Material Design styling */
body {
    background-color: var(--md-sys-color-surface);
    color: var(--md-sys-color-on-surface);
    margin-bottom: 5px;
}

main {
    background-color: var(--md-sys-color-surface);
}

h1, h2, h3, h4, h5, h6 {
    color: var(--md-sys-color-on-surface);
}

.text-primary {
    color: var(--md-sys-color-primary) !important;
}

.text-success {
    color: var(--md-sys-color-secondary) !important;
}

.bg-primary {
    background-color: var(--md-sys-color-primary) !important;
}

.bg-success {
    background-color: var(--md-sys-color-secondary) !important;
}

#volcanoPlot, #umapPlot {
    width: 800px;
}

/* Unified heatmap grid styling */
.heatmap-grid {
    display: flex;
    flex-wrap: wrap;
    max-width: 100%;
}

.heatmap-grid-collapsed {
    display: flex;
    overflow-x: auto;
    padding-bottom: 10px;
    max-width: 100%;
}

.heatmap-grid-collapsed .heatmap-cell {
    flex-shrink: 0;
    min-width: 20px;
    width: 20px;
}

.heatmap-cell {
    position: relative;
    border: 1px solid var(--md-sys-color-outline);
    padding: 2px;
    text-align: center;
    transition: all 0.2s ease-in-out;
    min-height: 80px;
    width: 20px;
    flex-shrink: 0;
    display: flex;
    flex-direction: column;
    justify-content: flex-end;
    align-items: center;
    font-size: 0.6rem;
    cursor: default;
}

.heatmap-cell:last-child {
    border-right: 1px solid var(--md-sys-color-outline);
}

.heatmap-grid .heatmap-cell:nth-last-child(-n+20) {
    border-bottom: 1px solid var(--md-sys-color-outline);
}

.heatmap-cell.interactive {
    cursor: pointer;
}

.heatmap-cell.interactive:hover {
    border-color: var(--md-sys-color-primary);
    box-shadow: 0 2px 4px rgba(0,0,0,0.1);
}

.heatmap-cell.knocked-out {
    background-color: #f5f5f5 !important;
    color: #999 !important;
    border-color: #ccc;
}

.heatmap-gene-name {
    font-weight: bold;
    font-size: 0.5rem;
    writing-mode: vertical-rl;
    text-orientation: mixed;
    transform: rotate(180deg);
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
    max-height: 60px;
    line-height: 1;
}

.heatmap-expression {
    display: none;
}

.uncertainty-dot {
    width: 6px;
    height: 6px;
    border-radius: 50%;
    margin-top: 2px;
    flex-shrink: 0;
}

.uncertainty-value {
    display: none;
}

.heatmap-tooltip {
    position: absolute;
    background: rgba(0, 0, 0, 0.9);
    color: white;
    padding: 4px 8px;
    border-radius: 4px;
    font-size: 0.7rem;
    white-space: nowrap;
    z-index: 1000;
    pointer-events: none;
    opacity: 0;
    transition: opacity 0.2s;
}

.heatmap-tooltip.show {
    opacity: 1;
}

.knockout-slash {
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: linear-gradient(45deg, transparent 45%, #ff0000 45%, #ff0000 55%, transparent 55%);
    pointer-events: none;
    border-radius: 8px;
}

/* Expression level colors */
.expr-low {
    background-color: #e3f2fd;
    -color: #1565c0;
}

.expr-low-med {
    background-color: #bbdefb;
    -color: #1976d2;
}

.expr-medium {
    background-color: #fff3e0;
    -color: #f57c00;
}

.expr-med-high {
    background-color: #ffccbc;
    -color: #e64a19;
}

.expr-high {
    background-color: #ffebee;
    -color: #c62828;
}

/* Uncertainty level colors (using purple-orange colormap) */
.uncert-very-low {
    background-color: #440154;
    color: white;
}

.uncert-low {
    background-color: #31688e;
    color: white;
}

.uncert-medium {
    background-color: #35b779;
    color: white;
}

.uncert-high {
    background-color: #fde725;
    color: black;
}

.uncert-very-high {
    background-color: #ff6600;
    color: white;
}

/* Heatmap container styling */
.heatmap-container {
    width: 100%;
}

.heatmap-title {
    font-weight: bold;
    margin-bottom: 10px;
    text-align: center;
    font-size: 1.1rem;
}

.heatmap-cell.empty {
    border: none;
    background: none;
}

/* Colorbar styling */
.heatmap-colorbars {
    display: flex;
    justify-content: space-around;
    margin-bottom: 15px;
    padding: 10px;
    background-color: var(--md-sys-color-surface-container-low);
    border-radius: 8px;
    border: 1px solid var(--md-sys-color-outline-variant);
}

.colorbar-container {
    display: flex;
    flex-direction: column;
    align-items: center;
}

.colorbar-label {
    font-size: 0.8rem;
    font-weight: bold;
    margin-bottom: 5px;
    color: var(--md-sys-color-on-surface);
}

.colorbar {
    display: flex;
    border-radius: 4px;
    overflow: hidden;
    border: 1px solid var(--md-sys-color-outline);
}

.colorbar-item {
    padding: 4px 8px;
    font-size: 0.7rem;
    font-weight: 500;
    text-align: center;
    min-width: 40px;
}

/* Optimize page specific styles */
.clickable-umap {
    cursor: crosshair;
    position: relative;
}

#optimizeUmapPlot {
    width: 500px;
}

.target-overlay {
    position: absolute;
    width: 30px;
    height: 30px;
    border: 3px solid #28a745;
    border-radius: 50%;
    background-color: rgba(40, 167, 69, 0.2);
    pointer-events: none;
    z-index: 10;
}

.original-target {
    border: 3px solid #28a745 !important;
    background-color: rgba(40, 167, 69, 0.2) !important;
}

.result-overlay {
    position: absolute;
    width: 24px;
    height: 24px;
    border: 2px solid;
    border-radius: 50%;
    pointer-events: none;
    z-index: 11;
    opacity: 0.8;
}

.gene-combination-compact {
    display: flex;
    flex-wrap: wrap;
    gap: 1px;
}

.gene-combination-compact .badge {
    font-size: 0.65rem !important;
    padding: 2px 4px;
}

.result-row:hover {
    background-color: var(--md-sys-color-surface-container-low) !important;
}

.gene-combination {
    display: flex;
    flex-wrap: wrap;
    gap: 2px;
}

.gene-combination .badge {
    font-size: 0.75rem;
}

/* Results table styling */
.table-responsive {
    border-radius: 12px;
    overflow: hidden;
}

.table {
    margin-bottom: 0;
}

.table th {
    background-color: var(--md-sys-color-surface-container);
    color: var(--md-sys-color-on-surface);
    border-color: var(--md-sys-color-outline-variant);
    font-weight: 600;
}

.table td {
    border-color: var(--md-sys-color-outline-variant);
    vertical-align: middle;
}

.table-striped > tbody > tr:nth-of-type(odd) > td {
    background-color: var(--md-sys-color-surface-container-low);
}

/* Feature card styles */
.explore-card i {
    color: var(--md-sys-color-primary) !important;
}

.explore-card .btn {
    background-color: var(--md-sys-color-primary);
    border-color: var(--md-sys-color-primary);
    color: var(--md-sys-color-on-primary);
    border-radius: 20px;
    padding: 8px 24px;
    font-weight: 500;
    transition: all 0.2s ease-in-out;
}

.explore-card .btn:hover {
    background-color: var(--md-sys-color-primary-container);
    border-color: var(--md-sys-color-primary-container);
    color: var(--md-sys-color-on-primary-container);
    box-shadow: var(--md-sys-elevation-level2);
}

.predict-card i {
    color: var(--md-extended-color-predict-color) !important;
}

.predict-card .btn {
    background-color: var(--md-extended-color-predict-color);
    border-color: var(--md-extended-color-predict-color);
    color: var(--md-sys-color-on-secondary);
    border-radius: 20px;
    padding: 8px 24px;
    font-weight: 500;
    transition: all 0.2s ease-in-out;
}

.predict-card .btn:hover {
    background-color: var(--md-extended-color-predict-color-container);
    border-color: var(--md-extended-color-predict-color-container);
    color: var(--md-extended-color-predict-on-color-container);
    box-shadow: var(--md-sys-elevation-level2);
}

.optimize-card i {
    color: var(--md-extended-color-optimize-color) !important;
}

.optimize-card .btn {
    background-color: var(--md-extended-color-optimize-color);
    border-color: var(--md-extended-color-optimize-color);
    color: var(--md-extended-color-optimize-on-color);
    border-radius: 20px;
    padding: 8px 24px;
    font-weight: 500;
    transition: all 0.2s ease-in-out;
}

.optimize-card .btn:hover {
    background-color: var(--md-extended-color-optimize-color-container);
    border-color: var(--md-extended-color-optimize-color-container);
    color: var(--md-extended-color-optimize-on-color-container);
    box-shadow: var(--md-sys-elevation-level2);
}

/* Editable heatmap cell styles */
.editable-cell {
    position: relative;
    min-height: 100px;
    width: 60px;
}

.expression-controls {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 1px;
    margin-top: 2px;
}

.expression-btn {
    background: var(--md-sys-color-primary);
    color: var(--md-sys-color-on-primary);
    border: none;
    border-radius: 50%;
    width: 16px;
    height: 16px;
    font-size: 10px;
    font-weight: bold;
    cursor: pointer;
    display: flex;
    align-items: center;
    justify-content: center;
    transition: all 0.2s ease-in-out;
    z-index: 10;
}

.expression-btn:hover {
    background: var(--md-sys-color-primary-container);
    color: var(--md-sys-color-on-primary-container);
    transform: scale(1.1);
}

.expression-btn:active {
    transform: scale(0.95);
}

.expression-value {
    font-size: 0.7rem;
    font-weight: bold;
    color: var(--md-sys-color-on-surface);
    cursor: pointer;
    padding: 1px 3px;
    border-radius: 3px;
    transition: background-color 0.2s ease-in-out;
    min-width: 20px;
    text-align: center;
}

.expression-value:hover {
    background-color: var(--md-sys-color-primary-container);
    color: var(--md-sys-color-on-primary-container);
}

.edited-cell {
    border: 2px solid var(--md-sys-color-tertiary) !important;
    box-shadow: 0 0 4px rgba(0,0,0,0.2);
}

.edited-indicator {
    position: absolute;
    top: 2px;
    right: 2px;
    font-size: 8px;
    color: var(--md-sys-color-tertiary);
    background: var(--md-sys-color-tertiary-container);
    border-radius: 50%;
    width: 12px;
    height: 12px;
    display: flex;
    align-items: center;
    justify-content: center;
    z-index: 10;
}

/* Adjust heatmap grid for editable cells */
.heatmap-grid .editable-cell {
    width: 60px;
    min-height: 100px;
}

.heatmap-grid-collapsed .editable-cell {
    width: 40px;
    min-height: 80px;
}

.heatmap-grid-collapsed .expression-controls {
    gap: 0;
}

.heatmap-grid-collapsed .expression-btn {
    width: 12px;
    height: 12px;
    font-size: 8px;
}

.heatmap-grid-collapsed .expression-value {
    font-size: 0.6rem;
}

/* Loading spinner overlay */
.loading-spinner-overlay {
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    background-color: rgba(0, 0, 0, 0.7);
    display: flex;
    justify-content: center;
    align-items: center;
    z-index: 9999;
    opacity: 0;
    transition: opacity 0.3s ease-in-out;
}

.loading-spinner-overlay.show {
    opacity: 1;
}

.loading-spinner-content {
    display: flex;
    flex-direction: column;
    align-items: center;
    background-color: var(--md-sys-color-surface-container);
    padding: 2rem;
    border-radius: 16px;
    box-shadow: var(--md-sys-elevation-level3);
    min-width: 200px;
}

.loading-spinner {
    font-size: 3rem;
    color: var(--md-sys-color-primary);
    margin-bottom: 1rem;
}

.loading-spinner i {
    animation: spin 1s linear infinite;
}

@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

.loading-message {
    color: var(--md-sys-color-on-surface);
    font-size: 1.1rem;
    font-weight: 500;
    text-align: center;
}

/* Responsive adjustments */
@media (max-width: 768px) {
    .heatmap-cell {
        min-height: 50px;
        width: 50px;
        font-size: 0.7rem;
    }
    
    .editable-cell {
        width: 50px;
        min-height: 80px;
    }
    
    .expression-btn {
        width: 14px;
        height: 14px;
        font-size: 9px;
    }
    
    .expression-value {
        font-size: 0.6rem;
    }
    
    .clickable-umap {
        max-width: 100%;
        height: auto;
    }
    
    .target-overlay {
        width: 20px;
        height: 20px;
    }
    
    /* Add vertical spacing between cards on mobile */
    .col-md-4 {
        margin-bottom: 1rem;
    }
    
    .loading-spinner-content {
        padding: 1.5rem;
        min-width: 150px;
    }
    
    .loading-spinner {
        font-size: 2.5rem;
    }
    
    .loading-message {
        font-size: 1rem;
    }
}